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Effectiveness of the first half intensive hemodiafiltration on the removal of low molecular weight proteins
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- Nagaoka Yume
- Department of Nephrology, Tokyo Medical University
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- Nakao Toshiyuki
- Department of Nephrology, Tokyo Medical University
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- Matsumoto Hiroshi
- Department of Nephrology, Tokyo Medical University
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- Okada Tomonari
- Department of Nephrology, Tokyo Medical University
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- Han Myongi
- Department of Nephrology, Tokyo Medical University
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- Takeguchi Humihiro
- Department of Nephrology, Tokyo Medical University
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- Iwasawa Hideaki
- Department of Nephrology, Tokyo Medical University
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- Tomaru Ryo
- Department of Nephrology, Tokyo Medical University
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- Wada Toshikazu
- Department of Nephrology, Tokyo Medical University
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- Gondo Asako
- Department of Nephrology, Tokyo Medical University
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- Sugio Mayumi
- Medical Engineering, Tokyo Medical University
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- Ogata Akinobu
- Medical Engineering, Tokyo Medical University
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- Goto Kazuhiro
- Medical Engineering, Tokyo Medical University
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- Niwayama Yuko
- Medical Engineering, Tokyo Medical University
Bibliographic Information
- Other Title
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- 前半集中置換式血液透析ろ過療法による物質除去効率向上の検討
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Description
Hemodiafiltration (HDF) treatment is effective for removing low molecular weight proteins. To investigate whether the amounts of low molecular weight proteins removed could be increased by changing the filtration procedure using an equal amount of replacement fluid, we newly devised a first half intensive HDF that replaces 10L of fluids during the first 2 hours of a 4-hour treatment (HDF2), and compared this regimen with both conventional 4-hour hemodialysis (HD) and hemodiafiltration replacing 10L at a constant rate over 4 hours (HDF4). Each treatment was performed 8-9 times in a patient with end stage renal disease, and we measured the removal of β2-microglobulin (β2MG), α1-microglubulin (α1MG), urea, creatinine, phosphate and albumin, and the serum concentrations of these substances. The removed amounts and clear spaces of β2MG and α1MG were greater in HDF2 than in either HD or HDF4. Furthermore, albumin loss by HDF2 was also greater than that by either HD or HDF4. However, the amounts of urea, creatinine and phosphate removed did not significantly differ among HDF2, HD and HDF4. In HDF2, β2MG and α1MG were removed in a concentrated manner during the first 2 hours of the 4-hour treatment. This study suggested that removal of low molecular weight proteins depends on filtration speed rather than the amount of fluid replaced. In conclusion, this new method of HDF more effectively removed low molecular weight proteins than conventional constantly replacing HDF.
Journal
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- Nihon Toseki Igakkai Zasshi
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Nihon Toseki Igakkai Zasshi 38 (6), 1299-1304, 2005
The Japanese Society for Dialysis Therapy
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Details 詳細情報について
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- CRID
- 1390001204674546688
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- NII Article ID
- 130003875363
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- ISSN
- 1883082X
- 13403451
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed