蛋白結合性尿毒症毒素であるフランカルボン酸のミトコンドリア呼吸抑制作用

DOI

書誌事項

タイトル別名
  • Inhibitory effect of furancarboxylic acid, a protein-bound uremic toxin, on mitochondrial respiration.
公開日
1992
DOI
  • 10.4009/jsdt1985.25.369
公開者
社団法人 日本透析医学会

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説明

The accumulation of 3-carboxy-4-rrmethyl-5-propyl-2-furanpropionic acid (CMPF) and indoxyl sulfate, as albumin-bound uremic toxins, occurs in the serum of uremic patients and these compounds cannot be efficiently removed by hemodialysis. To determine the pathogenic roles of CMPF and indoxyl sulfate in uremic patients, their cellular toxicities, as manifested by their effects on mitochondrial respiration, were studied.<br>CMPF showed dose-dependent inhibition of NADH-linked mitochondrial state 3 respiration. The inhibition was also observed in the presence of serum albumin, and even at a concentration of 50μg/ml, which is comparable to the serum level of CMPF in uremic patients on regular hemodialysis treatment. Indoxyl sulfate, however, showed much weaker inhibition of mitochondrial respiration as compared to CMPF.<br>These results suggest that CMPF is toxic to cells due to inhibition of energy (ATP) synthesis secondary to impaired mitochondrial respiration.

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