Low urinary detection rates of human polyomaviruses BKV and JCV in chronic hemodialysis patients.

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  • 慢性血液透析患者の尿中ヒト・ポリオーマウイルス（ＢＫＶ，ＪＣＶ）検出率の検討

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JC virus is one of the human polyomviruses and is the causative agent of progressive multifocal leucoencephalopathy (PML). In the current study, we determined the urinary detection rates of BKV and JCV in chronic hemodialysis patients.<br>By using the PCR-Southern method, urinary BKV and JCV DNAs were examined in 47 patients on chronic hemodialysis along with 47 age- and sex-matched patients with urological diseases whose renal function was within the normal range. Urinary detection rates of BKV and JCV were lower in the hemodialysis group than in the controls, and a similar tendency was observed in urinary virus concentrations. However, there was no significant difference between subgroups with moderate daily urine volume and with almost none. Since the kidneys are severely damaged in patients with chronic renal failure, collecting tubules, which are the sites of human polyomavirus infection, seem to be destroyed at a high level. This will be the cause of the decreased rates of detection and concentration in both BKV and JCV infection. Nevertheless, PML has been found in chronic hemodialysis patients. The unknown mechanism of PML development in such patients should be investigated.

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