Clinical effect of percutaneous maxacalcitol injection therapy on advanced secondary hyperparathyroidism-The predictive value of whole PTH assay-
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- Shiizaki Kazuhiro
- Center of Blood Purification Therapy, Wakayama Medical University
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- Negi Shigeo
- Center of Blood Purification Therapy, Wakayama Medical University
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- Hanba Yoshiyuki
- Center of Blood Purification Therapy, Wakayama Medical University
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- Kodama Naoya
- Department of Internal Medicine, Kodama Hospital
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- Kodama Toshihiro
- Department of Internal Medicine, Kinokawa Clinic
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- Ujita Takuji
- Ujita Circulation Disease Clinic
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- Shima Wataru
- Shima Hospital
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- Kinoshita Keinosuke
- Matsuo Surgical Clinic
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- Akizawa Tadao
- Center of Blood Purification Therapy, Wakayama Medical University
Bibliographic Information
- Other Title
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- 進行した二次性副甲状腺機能こう進症に対するmaxacalcitol副甲状腺内直接注入療法の効果―PTH抑制の評価と予測因子としてのwhole PTH―
- The predictive value of whole PTH assay
- PTH抑制の評価と予測因子としてのwhole PTH
Abstract
Percutaneous maxacalcitol (OCT) injection therapy (PMIT) has been developed as an effective and safe treatment for advanced secondary hyperparathyroidism (SHPT). The effect of PMIT on PTH suppression was evaluated by intact PTH, highly sensitive (HS) PTH, and whole PTH assays.<br>Eight dialysis patients with SHPT resistant to intravenous OCT administrations were consecutively treated by PMIT six times a week followed by OCT intravenous administrations (iv OCT). Serum intact PTH, HS PTH, whole PTH, Ca adjusted for albumin, and P levels were measured before, immediately, 4 and 12 weeks after PMIT.<br>After PMIT, serum intact PTH, HS PTH, and whole PTH levels were significantly decreased, however serum adjusted Ca and P levels did not change significantly. Whole PTH/C PTH (calculated by intact-PTH-whole PTH) ratio was also significantly decreased immediately after PMIT. In five patients whose PTH levels were controlled by iv OCT for more than 6 months after PMIT (effective group), the decrease in whole PTH level after PMIT was significantly greater compared with that in the ineffective group whose PTH levels could not be controlled by iv OCT.<br>It is suggested that whole PTH difference immediately after PMIT compared to that before may predict the effect of PMIT.
Journal
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- Nihon Toseki Igakkai Zasshi
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Nihon Toseki Igakkai Zasshi 37 (5), 1311-1316, 2004
The Japanese Society for Dialysis Therapy
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Keywords
Details 詳細情報について
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- CRID
- 1390001204677003392
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- NII Article ID
- 130003875233
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- ISSN
- 1883082X
- 13403451
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed