Analysis of current perception threshold (CPT) using PainVision PS-2100 in hemodialysis patients

DOI Web Site 2 Citations 24 References
  • Gohda Tomohito
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine
  • Oka Hiroshi
    Institute of Medical Science, St. Marianna University School of Medicine
  • Gotoh Hiromichi
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine Saiyu Soka Hospital
  • Sato Michiko
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine
  • Tanimoto Mitsuo
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine
  • Io Hiroaki
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine
  • Shimizu Yoshio
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine
  • Hamada Chieko
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine
  • Horikoshi Satoshi
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine
  • Tomino Yasuhiko
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine

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Other Title
  • 血液透析患者におけるＰａｉｎＶｉｓｉｏｎ　ＰＳ‐２１００を用いた電流知覚閾値（ＣＰＴ）の検討
  • 血液透析患者におけるPainVision PS-2100を用いた電流知覚閾値(CPT)の検討
  • ケツエキ トウセキ カンジャ ニ オケル PainVision PS 2100 オ モチイタ デンリュウ チカク イキチ CPT ノ ケントウ

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Abstract

Purpose : To evaluate the usefulness of PainVision® PS-2100 as an indicator of sensory nerve dysfunction, the current perception threshold (CPT) was examined in hemodialysis (HD) patients. Patients and Methods : HD patients at Juntendo University were recruited in this study and 61 HD patients (male 36/female 25) and 112 normal controls (male 52/female 60) were enrolled. CPT was evaluated before and after HD therapy. Results : The CPT levels in HD patients were significantly higher than those in normal controls. Before HD therapy, CPT levels in the hand in which arteriovenous fistula was created (shunt side) were significantly higher compared with those in the opposite hand (non-shunt side) (pre HD ; shunt side : 14.7±5.8μA, non-shunt side : 12.3±4.4μA, p<0.0001). The CPT levels before HD therapy both on the shunt and non-shunt side of male patients were significantly higher them those in female patients (shunt side ; male 16.6±6.1μA, female 12.0±4.1μA, p<0.002, non-shunt side ; male 13.4±4.5μA, female 10.7±3.7μA, p<0.02). The CPT levels after HD therapy were significantly decreased both on the shunt and non-shunt side (shunt side, pre HD : 14.7±5.8μA, post HD : 13.4±6.5μA, p=0.04, non-shunt side, pre HD : 12.3±4.4μA, post HD 10.6±3.2μA, p<0.002) than those before HD therapy. Before HD therapy, there was no significant difference in the CPT level on either the shunt or non-shunt side on a comparison between diabetic and non diabetic patients. Age, gender and presence of chronic renal failure were identified as independent risk factors for CPT levels on multivariate regression analysis. Conclusion : It appeared that measuring CPT level regularly using PainVision® PS-2100 would be useful to detect the early stage of sensory nerve dysfunction.

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