肺小細胞癌におけるＮＳＥ（Ｎｅｕｒｏｎ　ｓｐｅｃｉｆｉｃ　ｅｎｏｌａｓｅ）の腫ようマーカーとしての意義

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  • Significance of serum neuron-specific enolase (NSE) as a tumor marker in small cell lung cancer patients.

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Serum levels of neuron-specific enolase (NSE) in 69 cases of newly diagnosed lung cancer (22 small cell carcinoma, 27 adenocarcinoma, 15 squamous cell carcinoma and 5 large cell carcinoma), 23 cases of benign pulmonary diseases and 51 controls were measured by radioimmunoassay. The mean level of serum NSE in small cell carcinoma was significantly higher than those of the other groups. An abnormal serum NSE level was defined as a value of more than 12.50ng/ml. Sixteen out of 22 cases of small cell carcinoma and four out of 47 cases of non-small cell carcinoma had elevated (>12.50ng/ml) serum NSE levels.<BR>In small cell carcinoma, serum NSE levels were elevated in 12 out of 14 cases with extensive disease, and in four out of eight cases with limited disease, respectively, at the time of initial diagnosis. The mean serum NSE level of extensive stage cases was significantly higher (40.88ng/ml) than that of limited stage cases (12.84ng/ml). Serum NSE levels were measured serially in 21 cases of small cell carcinoma during therapy (one CR case, 19 PR cases, one NC case). NSE fell within the normal range in response to therapy in all cases with elevated NSE levels before therapy. Serum NSE levels were measured in 11 cases at relapse, and all cases showed elevation in serum NSE levels compared with those at remission.<BR>Serum NSE was therefore thought to be a useful marker for monitoring the course of small cell lung cancer patients.

収録刊行物

  • 肺癌

    肺癌 27 (1), 23-29, 1987

    特定非営利活動法人 日本肺癌学会

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