原発性肺癌におけるCA19-9の意義 : 血中濃度と組織内局在の検討

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タイトル別名
  • The carbohydrate antigen 19-9 in serum and tissue of patients with lung cancer.
  • 原発性肺癌におけるＣＡ　１９‐９の意義　　血中濃度と組織内局在の検討
  • 血中濃度と組織内局在の検討

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説明

The 19-9 monoclonal antibody, prepared by Koprowski et al., reacts with a carbohydrate antigenic determinant (CA 19-9) which has been identified as a sialylated lacto-Nfucopentaose II. CA19-9 has been known to be a useful tumor marker for gastrointestinal carcinoma, especially pancreatic cancer.<BR>The authors investigated the significance of this antigen for lung cancer. We measured serum CA 19-9 concentration in 56 patients with lung cancer by a forward sandwich type radioimmunometric assay (cut-off value 37 U/ml), and immunostained the antigen in 32 lung cancer tissue by an immunoperoxidase assay.<BR>The positive rate of serum CA 19-9 concentration was 16%, lower than that of carcinoembryonic antigen (CEA). The concentration of the antigen was markedly increased in patients with bronchial gland type adenocarcinoma, and strongly stained in cancer tissue.

収録刊行物

  • 肺癌

    肺癌 28 (1), 11-17, 1988

    特定非営利活動法人 日本肺癌学会

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