Proposal of daignostic criteria for calciphylaxis based on nationwide surveillance in Japan

DOI Web Site 3 Citations 19 References
  • Hayashi Matsuhiko
    The Japanese Calciphylaxis Study Group Apheresis and Dialysis Center, Keio University, School of Medicine
  • Takamatsu Ichiro
    Apheresis and Dialysis Center, Keio University, School of Medicine
  • Yoshida Tadashi
    Apheresis and Dialysis Center, Keio University, School of Medicine
  • Kanno Yoshihiko
    Apheresis and Dialysis Center, Keio University, School of Medicine
  • Sato Yuji
    Center for Clinical Research, Keio University, School of Medicine
  • Abe Takayuki
    Center for Clinical Research, Keio University, School of Medicine
  • Hashiguchi Akinori
    The Japanese Calciphylaxis Study Group Department of Pathology, Keio University, School of Medicine
  • Hosoya Tatsuo
    The Japanese Calciphylaxis Study Group Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine
  • Akiba Takashi
    The Japanese Calciphylaxis Study Group Department of Blood Purification, Kidney Center, Tokyo Women's Medical University
  • Nakamoto Hidetomo
    The Japanese Calciphylaxis Study Group Department of General Internal Medicine, Saitama Medical University
  • Umezawa Akihiro
    The Japanese Calciphylaxis Study Group Department of Reproductive Biology, Center for Regenerative Medicine, National Institute for Child Health and Development
  • Shigematsu Takashi
    The Japanese Calciphylaxis Study Group Division of Nephrology and Blood Purification Medicine, Department of Medicine,Wakayama Medical University
  • Fukagawa Masafumi
    The Japanese Calciphylaxis Study Group Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine
  • Kawamura Tetsuya
    The Japanese Calciphylaxis Study Group Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine
  • Tanaka Masaru
    The Japanese Calciphylaxis Study Group Department of Dermatology, Tokyo Women's Medical University Medical Center East
  • Sugino Yoshinori
    The Japanese Calciphylaxis Study Group Center for Preventive Medicine, Keio University, School of Medicine

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Other Title
  • 全国調査に基づくカルシフィラキシス診断基準の提案
  • ゼンコク チョウサ ニ モトズク カルシフィラキシス シンダン キジュン ノ テイアン

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Abstract

Calciphylaxis is a rare and often fatal complication of end-stage renal disease, and is characterized by painful skin ulceration. The main pathological findings are medial calcification and edematous intimal proliferation of small arteries. There had been little information regarding the prevalence and clinical features of calciphylaxis in Japan before our group conducted a nationwide survey in a Japanese dialysis population in 2009 as the study of “Research on Intractable Disease of Health and Labour Sciences Research Grants” from the Ministry of Health and Labour. The prevalence of calciphylaxis was speculated to be much lower than that in Western countries, and the lack of knowledge on the disease was suggested be related to this low prevalence. Therefore, to facilitate the diagnosis of calciphylaxis and spread knowledge of it, we proposed diagnostic criteria based on nationwide surveillance. These criteria must be reviewed by the accumulation of cases, while this attempt should promote caution regarding calciphylaxis.

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