書誌事項
- タイトル別名
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- Lymphokine (IL-2)-activated killer (LAK) activity and its regulation by blood monocytes in patients with lung cancer.
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The effect of lung cancer on the ability of blood lymphocytes to generate lymphokine (IL-2)-activated killer (LAK) activity and of monocytes to regulate the LAK induction were examined. Highly purified lymphocytes (> 99%) and monocytes (> 90%) were separated by counter-flow centrifugal elutriation. LAK activity against Daudi cells was measured by 4-hr 51Cr release assay. Results showed that the abilities of blood lymphocytes of healthy donors and lung cancer patients to generate LAK activity were similar. Blood monocytes of lung cancer patients significantly augmented the LAK induction at similar levels as did monocytes of healthy donors. When monocytes were stimulated with endotoxin, the monocytes of all healthy donors markedly suppressed LAK induction, whereas the LAK induction was suppressed by monocytes obtained from 7 out of 12 cancer patients, but augmented by monocytes from the remaining 5 patients. Thus, lymphocytes of patients with lung cancer can respond to IL-2 by generating LAK activity, which can be up-regulated by fresh monocytes. These findings indicate that the adoptive immunotherapy with LAK cells and IL-2 could be useful in the treatment of lung cancer.
収録刊行物
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- 肺癌
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肺癌 30 (2), 223-229, 1990
特定非営利活動法人 日本肺癌学会
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詳細情報 詳細情報について
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- CRID
- 1390001204679180160
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- NII論文ID
- 110003120648
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- NII書誌ID
- AN00203978
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- ISSN
- 13489992
- 03869628
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可