Inverse correlation of free triiodothyronine (FT3) and glycated albumin (GA) values in diabetic and non-diabetic patients on maintenance hemodialysis

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  • 糖尿病と非糖尿病の透析患者におけるグリコアルブミン (GA) とfree triiodothyronine (FT3) の逆相関関係の検討
  • トウニョウビョウ ト ヒトウニョウビョウ ノ トウセキ カンジャ ニ オケル グリコアルブミン(GA)ト free triiodothyronine (FT3)ノ ギャクソウカン カンケイ ノ ケントウ

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【Objective】This study aimed to prove the effects of FT3 on GA in diabetic and non-diabetic patients on maintenance hemodialysis. 【Patients and Methods】We examined the associations between GA (or FT3) values and several clinical variables in 49 diabetic and 49 non-diabetic patients on maintenance hemodialysis. 【Results】In the 49 diabetic patients, the average plasma glucose (PG) showed a significant positive correlation and only FT3 showed a significant negative correlation with GA. By stepwise multivariate regression analysis, PG was positively associated and only FT3 was negatively associated with GA. In the 49 non-diabetic patients, age and PG showed significant positive correlations, and body mass index (BMI), albumin, P, FT3, and Cr showed significant negative correlations with GA. By stepwise multivariate regression analysis, age was positively associated, and BMI and P were negatively associated with GA. In diabetic patients, BMI showed a significant positive correlation, and GA and TSH showed significant negative correlations with FT3. By stepwise multivariate regression analysis, BMI was positively associated and only GA was negatively associated with FT3. In non-diabetic patients, BMI, Alb, and Cr showed significant positive correlations, and age and GA showed significant negative correlations with FT3. By stepwise multivariate regression analysis, Cr was negatively associated and BMI was positively associated with FT3. 【Conclusion】GA values are more influenced by FT3 independently of glycemia in diabetic patients than in non-diabetic ones.

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