A prospective study of denosumab as a treatment for osteoporosis in hemodialysis patients

Nagasaku Daisuke, Takahashi Ryohei

doi:10.4009/jsdt.50.247

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骨粗鬆症を合併する外来透析患者に対するデノスマブ治療に関する前向き臨床研究—治療開始1年間の経過—
骨粗鬆症を合併する外来透析患者に対するデノスマブ治療に関する前向き臨床研究 : 治療開始1年間の経過
コツソショウショウオガッペイスルガイライトウセキカンジャニタイスルデノスマブチリョウニカンスルマエムキリンショウケンキュウ : チリョウカイシ 1ネンカンノケイカ

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<p>Denosumab treatment was administered to hemodialysis outpatients who were complicated with osteoporosis (young adult mean:<70%). Thirty-eight consecutive patients (13 males, 25 females; mean age: 70.8 years; range: 23-94 years) were recruited into this study. Sixty mg of denosumab were administered subcutaneously every 6 months. Twelve months later, the patients’ bone mineral density (BMD) at the 1/3 distal radius was significantly increased (by 4.63±7.07%). The levels of tartrate-resistant acid phosphatase 5b (TRACP-5b, a bone absorption marker) and total procollagen I intact N-terminal (P1NP, a bone formation marker) were significantly reduced after the administration of denosumab for more than 12 months. Although the patients’ albumin-adjusted calcium (Ca) levels decreased rapidly until the second or third week of denosumab treatment, their hypocalcemia gradually improved after the administration of a Ca and vitamin D preparation. The albumin-adjusted Ca, inorganic phosphate, and intact-parathyroid hormone (intact-PTH) levels detected after the second administration of denosumab were significantly lower than those recorded after the first administration of the drug, and therefore, the need for Ca adjustment could be reduced by half. In addition, the patients’ intact-PTH, TRACP-5b, and total P1NP levels were correlated with the reductions in their albumin-adjusted Ca levels. Denosumab treatment improved BMD at the 1/3 distal radius in hemodialysis patients that were complicated with osteoporosis.</p>

Journal

Nihon Toseki Igakkai Zasshi

Nihon Toseki Igakkai Zasshi 50 (4), 247-253, 2017

The Japanese Society for Dialysis Therapy

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