スナネズミ耳下腺および顎下腺腺房細胞における老齢化に伴う細胞死に関する形態学的研究

DOI 被引用文献3件 参考文献40件

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  • Morphological studies of cell death in Mongolian gerbil parotid and submandibular gland acinar cells during aging.

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The purpose of the present report was to study ultrastructurally the relation between aging and cell death in salivary glands. The parotid and submandibular glands of 3 to 39-month-old Mongolian gerbils were used. Four types of acinar cells, which were considered to be in the process of cell death were distinguished: (a) acinar cells having apoptosis-like chromatin condensation of the nucleus (Type I); (b) acinar cells characterized by dilated cistenae of rough-surfaced endoplasmic reticulum and chromatin condensation in the nucleus (Type II); (c) acinar cells having typical necrotic characters (Type III); and (d) acinar cells having conspicuous vacuoles and characteristic chromatin condensation in the nucleus (Type IV).<BR>Dispersed Type I cells were observed in the parotid gland, and had a tendency to increase slightly in number after 36 months. Types II, III, and IV cells were present in groups within the acini in the parotid and submandibular glands, with a tendency to increase in number after 18 months. Moreover, some apoptotic body-like structures were observed among the acinar cells, with a tendency to increase in number after 18 months.<BR>Acinar cells containing a TUNEL-positive nucleus were distinguished according to their distribution as follows: (1) TUNEL-positive cells, which were present singly within an acinus, were considered to correspond to the Type I cells; (2) TUNEL positive cells, which were found in a group, were regarded to correspond to either the Types II, III, or IV cells. In addition, granular TUNEL-positive reaction within cytoplasm, which may indicate the apoptotic body-like structures, was also sometimes seen.<BR>Thus, it is suggested that, these 4 types may relate to a decrease in acinar cells in the Mongolian gerbil parotid and submandibular glands.

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