Calcitonin gene-related peptide (CGRP)-immunoreactive nerve fibers in rat molars.

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  • ラット臼歯におけるカルシトニン遺伝子関連ペプチド（ｃａｌｃｉｔｏｎｉｎ　ｇｅｎｅ‐ｒｅｌａｔｅｄ　ｐｅｐｔｉｄｅ，ＣＧＲＰ）含有神経について

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By use of an immunohistochemical technique we investigated nerve fibers showing a calcitonin gene-related peptide (CGRP) immunoreactivity in rat molars under both light and electron microscopy. The CGRP-immunopositive nerve fibers entered into the dental pulp through the apical foramen, and were widely distributed in the coronal pulp. They were concentrated at the roof of pulp chamber, forming the subodontoblastic nerve plexus. A part of them further penetrated into the predentin of the pulp horn. In electron microscopic immunohistochemistry, CGRP-immunoreactive nerve fibers were identified as electron-dense elements, in which immunoreactivity for CGRP was localized mainly at a number of large cored vesicles. CGRP-nerve fibers occurred more frequently than any other peptidergic neurons which have been reported in the dental pulp. These findings suggested that CGRP is most important among the peptidergic neurons.

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