Chest Wall Metastasis of Anaplastic Lymphoma Kinase-positive Lung Adenocarcinoma 22 Years After Lobectomy

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  • Matsumoto Daisuke
    Department of Thoracic, Endocrine Surgery and Oncology, Tokushima University Graduate School
  • Takizawa Hiromitsu
    Department of Thoracic, Endocrine Surgery and Oncology, Tokushima University Graduate School
  • Takashima Mika
    Department of Thoracic, Endocrine Surgery and Oncology, Tokushima University Graduate School
  • Kawakami Yukikiyo
    Department of Thoracic, Endocrine Surgery and Oncology, Tokushima University Graduate School
  • Kondo Kazuya
    Department of Thoracic, Endocrine Surgery and Oncology, Tokushima University Graduate School
  • Tangoku Akira
    Department of Thoracic, Endocrine Surgery and Oncology, Tokushima University Graduate School

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Other Title
  • 肺葉切除22年後に胸壁転移を認めたALK融合遺伝子陽性肺癌の1例

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Description

<p>Background. When a new tumor appears after a long period of remission following surgery for lung cancer, it is difficult to determine whether the tumor is a recurrence or a new tumor. We herein report a case of a chest wall tumor that developed 22 years after pulmonary lobectomy diagnosed by an anaplastic lymphoma kinase (ALK) gene mutation. Case. An 80-year-old man underwent left-lung upper lobectomy for lung adenocarcinoma (pT4N2M0 Stage III) 22 years prior. We treated him with adjuvant chemotherapy after the surgery and did not detect a recurrence for 10 years. However, we noticed a chest wall mass 22 years after the surgery and diagnosed it by a biopsy as adenocarcinoma. The new specimen was stained with anti-thyroid transcription factor-1 (TTF-1) and anti-ALK antibodies, and the pathological specimen from the first surgery was also stained with anti-ALK antibody. We therefore diagnosed the chest wall tumor as a recurrence of the lung adenocarcinoma. We treated him with crizotinib, and the tumor shrank. However, we stopped the treatment because of the development of drug-induced interstitial pneumonia. We switched him to a platinum combination regimen, and follow-up is ongoing. Conclusions. When a lesion is suspected to be a recurrence long after surgery, an examination of gene mutations, such as that of ALK, may be useful.</p>

Journal

  • Haigan

    Haigan 56 (7), 1046-1050, 2016

    The Japan Lung Cancer Society

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