小児に対する抗生物質投与方法の検討

The authors administered persistant cephalexin (L-CEX) to forty-eight child patients who exhibited acute suppurative inflammation in their oral cavities, examined the clinical effects, and moreover, performed " questionnairing on drugs used ", using their mothers as subjects. The following conclusions were derived.<BR>1. The rate of efficacy of L-CEX was 70.8% and 91.7% with continuous dosages for three days and five days, respectively, in an objective rating method, and 93.7% according to subjective estimation of the doctors in charge. Thus, the satisfactory efficacy of L-CEX was apparent.<BR>2. Concomitant use of enzymic antiphogistics tended to increase the number of cases with remarkable effectiveness.<BR>3. Concerning side effects, four cases of slight diarrhea and one case each of nasal hemorrhage, vomiting or gastric dysphobia were observed. No particularly serious side effects were reported. Discontinuation was not necessary.<BR>4. High effectiveness was obtained in such a short period of time as three to five days in cases of various suppurative symptoms of the oral cavity. Because the safety factor was relatively high, too, L-CEX could be considered to be the first choice in this medical region.<BR>5. Because conventional antibiotics were not satisfactory in respect to their taste, odor, color and appearance, not a few children rejected taking them with reluctance. However, the majority of child patients took L-CEX without much reluctance, in some cases, voluntarily. No patient refused completely. Therefore, L-CEX may be considered to be easy for children to take.<BR>6. Conventional antibiotics required administration at every six-hour interval. Therefore, such regular administration frequently failed to be performed, because of sleeping at night and staying at nursery or school in the daytime. L-CEX can maintain satisfactory blood concentration by aministration at twelve-hour interval, and be given directly by parents in the morning and evening. These features of L-CEX could be considered to be important merits in preventing failure to administer it.