カイロミクロンおよびVLDL代謝における肝リパーゼとLPLの役割

DOI Web Site

書誌事項

タイトル別名
  • A Role of Hepatic Triglyceride Lipase and Lipoprotein Lipase on the Metabolism of Chylomicron and VLDL in Rats

この論文をさがす

説明

In various tissues the liver plays a major role in the clearance of plasma lipoprotein. The hydrolysis of triglyceride-rich lipoprotein (chylomicron and VLDL) is mediated by lipoprotein lipase (LPL) localized on the capillary endothelial surface and but the role of hepatic triglyceride lipase (HTGL) in lipoprotein metabolism is still not clear.<br>Recent studies indicated that the liver took up and hydrolyzed chylomicron-remnant, a product which chylomicron was degradated by LPL. In this study we have determined the fate of labeled chylomicron in circulating blood following intravenous injection in the normal and the supradiaphragmatic rat. And the effect of various sizes of chylomicron on the uptake of the lipoprotein in the liver was also investigated.<br>As a result, the apparent half-life of injected chylomicron was 2.5min in the normal rat and prolonged to more than 5min in the supradiaphragmatic rat. The radioactive ratio of triglyceride to cholesterol in the blood and the liver was not different from the labelled origin during 10min after the injection. The liver hydrolyzed the large-chylomicron far more efficiently than the middle or the small-chylomicron.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ