カイロミクロンの肝細胞での脂肪酸合成に及ぼす影響

DOI Web Site

書誌事項

タイトル別名
  • Regulation of Fatty Acid Synthesis in Isolated Hepatocytes by Intestinal Chylomicrons and Their Remnants

この論文をさがす

抄録

Dietary fatty acids are incorporated into chylomicrons and the chylomicron triglycerides are degraded by the action of lipoprotein lipase. The resultant particles, remnants, are selectively metabolized by the liver. This study was undertaken to examine the effects of chylomicrons and their remnants on fatty acid synthesis in isolated rat hepatocytes.<br>Chylomicrons in the medium containing postheparin rat serum significantly inhibited fatty acid synthesis in hepatocytes (p<0.001). On the other hand, chylomicrons in the medium containing preheparin rat serum caused very small inhibition (n. s.). Chylomicron remnants prepared in vitro caused significant inhibition (p<0.01) and remnants prepared from the chylomicrons injected into functionally hepatectomized rats, in vivo, inhibited fatty acid synthesis to a greater extent than unmetabolized chylomicrons at an equivalent protein concentration (p<0.05) and at an equivalent triglyceride concentration (p<0.01). Thus, the hepatocytes recognize the remnant but not the unmetabolized chylomicron. The chylomicron remnants produced by the action of lipoprotein lipase may play an important role in the regulation of hepatic fatty acid synthesis.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ