Regulation of Fatty Acid Synthesis in Isolated Hepatocytes by Intestinal Chylomicrons and Their Remnants

DOI Web Site
  • KOIZUMI Junji
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University
  • WATANABE Akira
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University
  • WAKASUGI Takanobu
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University
  • TATAMI Ryozo
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University
  • UEDA Kosei
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University
  • UEDA Ryosei
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University
  • KAMETANI Tomio
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University
  • HABA Toshihiro
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University
  • ITO Seigo
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University
  • MABUCHI Hiroshi
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University
  • TAKEDA Ryoyu
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University

Bibliographic Information

Other Title
  • カイロミクロンの肝細胞での脂肪酸合成に及ぼす影響

Search this article

Abstract

Dietary fatty acids are incorporated into chylomicrons and the chylomicron triglycerides are degraded by the action of lipoprotein lipase. The resultant particles, remnants, are selectively metabolized by the liver. This study was undertaken to examine the effects of chylomicrons and their remnants on fatty acid synthesis in isolated rat hepatocytes.<br>Chylomicrons in the medium containing postheparin rat serum significantly inhibited fatty acid synthesis in hepatocytes (p<0.001). On the other hand, chylomicrons in the medium containing preheparin rat serum caused very small inhibition (n. s.). Chylomicron remnants prepared in vitro caused significant inhibition (p<0.01) and remnants prepared from the chylomicrons injected into functionally hepatectomized rats, in vivo, inhibited fatty acid synthesis to a greater extent than unmetabolized chylomicrons at an equivalent protein concentration (p<0.05) and at an equivalent triglyceride concentration (p<0.01). Thus, the hepatocytes recognize the remnant but not the unmetabolized chylomicron. The chylomicron remnants produced by the action of lipoprotein lipase may play an important role in the regulation of hepatic fatty acid synthesis.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top