Abnormalities of Chylomicron Remnant Metabolism in Diabetics

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  • BOKU Akitoshi
    The Third Department of Internal Medicine, Hirosaki University School of Medicine
  • YANADA Atsuko
    The Third Department of Internal Medicine, Hirosaki University School of Medicine
  • ONUMA Tomio
    The Third Department of Internal Medicine, Hirosaki University School of Medicine
  • TSUTSUI Masahiro
    The Third Department of Internal Medicine, Hirosaki University School of Medicine
  • OCHIAI Shigeru
    The Third Department of Internal Medicine, Hirosaki University School of Medicine
  • TAKEBE Kazuo
    The Third Department of Internal Medicine, Hirosaki University School of Medicine

Bibliographic Information

Other Title
  • 糖尿病におけるカイロミクロンレムナントの代謝異常
  • ―アポ蛋白B48/B100比の治療による変動について―
  • -Changes of Apolipoprotein B-48/B-100 Ratio after Treatment-

Abstract

It is well recognized that chylomicron remnant is a risk factor for the development of atherosclerosis. We demonstrated in previous study that Chylomicron remnant was abnormaly accumulated in subjects with non-insulin-dependent diabetes mellitus (NIDDM). This study was designed to evaluate if its abnormality of chylomicron remnant was improved by diabetic treatment. Apolipoprotein (apo) B subfractions (apo B-100 and apo B-48) of VLDL and IDL in 19 subjects with NIDDM were analyzed before and after treatment, using SDS-PAGE method described by Kane et al. Apo B-48 ratio (apo B-48/apo B-100) was calculated. Treatment produced a significant decrease in apo B-48 ratio of VLDL from 0.042±0.014 to 0.029±0.016 (p<0.02). Apo B-48 ratio of IDL was significantly reduced from 0.023±0.012 to 0.012±0.011 (p<0.01). Total cholesterol, triglyceride and protein levels of VLDL were slightly reduced, though these changes were not significant. These levels of IDL were also changed in likewise. These results suggest that abnormal accumulation of chylomicron remnant might be improved by treatment in NIDDM.

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