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- KAWAMOTO Toshio
- First Department of Internal Medicine, Hiroshima University School of Medicine
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- HORIUCHI Itaru
- First Department of Internal Medicine, Hiroshima University School of Medicine
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- NISHIMURA Shoji
- First Department of Internal Medicine, Hiroshima University School of Medicine
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- HIND Fumiaki
- First Department of Internal Medicine, Hiroshima University School of Medicine
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- MATSUO Nobutaka
- First Department of Internal Medicine, Hiroshima University School of Medicine
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- OKAHASHI Makoto
- First Department of Internal Medicine, Hiroshima University School of Medicine
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- OHKI Masami
- First Department of Internal Medicine, Hiroshima University School of Medicine
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- OYAMADA Ken
- First Department of Internal Medicine, Hiroshima University School of Medicine
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- YAMAMOTO Masaharu
- First Department of Internal Medicine, Hiroshima University School of Medicine
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- MITSUBA Koso
- Department of Internal Medicine, Chuden Hospital
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- TSUBOKURA Tokuo
- Department of Clinical Pathology, Hiroshima University School of Medicine
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- KAJIYAMA Goro
- First Department of Internal Medicine, Hiroshima University School of Medicine
Bibliographic Information
- Other Title
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- リポ蛋白成分の胆汁中排泄についての検討
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Abstract
We tried to prove the hypothesis that apolipoproteins, the protein constituents of plasma lipoproteins, are secreted into bile. We examined human gallbladder bile obtained at surgery (N=54) from subjects with (N=44) and without (N=10) gallstones and hepatic bile collected by T-tube drainage (N=9) after cholecystectomy.<br>Using specific radioimmunoassays for human apolipoproteins A-I and A-II, the major apolipo-proteins of high density lipoproteins, for apolipo-proteins C-II and C-III, major apolipoproteins of very low density lipoproteins, we found immuno-reactivity for these four apolipoproteins in every bile samples.<br>Using immunodiffusion technique, we observed complete lines of identity between bile samples and purified apolipoproteins A-I and A-II, or C-II.<br>Using molecular sieve chromatography, we found identical elution profiles of biliary apolipo-proteins A-I and A-II, as those of apolipoproteins A-I and A-II purified from human plasma.<br>When we added high density lipoproteins purified from human plasma to lipoprotein-free solutions perfusing through isolated rat livers, we detected apolipoproteins A-I and A-II in bile.<br>These data indicate that apolipoproteins can be transported across the hepatocyte and secreted into bile.
Journal
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- The Journal of Japan Atherosclerosis Society
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The Journal of Japan Atherosclerosis Society 12 (2), 235-243, 1984
Japan Atherosclerosis Society
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Details 詳細情報について
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- CRID
- 1390001204693151872
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- NII Article ID
- 130006853330
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- ISSN
- 21858284
- 03862682
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed