腹水中に巨核球の出現をみた骨髄線維症の１例

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  • A case of myelofibrosis with megakaryocytes in ascites.

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A case of myelofibrosis with ascites is reported. A 75-year-old women was admitted because of increase in body weight and abdominal fullness. Many multinucleate cells, both erythrocytic and granulocytic, were found in the peritoneal fluid. These large multinucleate cells were positive for PAS Stain and immunologically positive for Factors V III and GP III a, and were found to be megakaryocytes. We believe that in this case the hematopoietic cells in the ascitic fluid resulted from extramedullary hematopoiesis in the peritoneum. In cytologic examination of the peritoneal fluid, it is important to differenciate between megakaryocytes and other malignant cells such as poorly differentiated carcinoma and sarcoma. In this case, PAS stain and immunological study were effective methods for the differential diagnosis of large multinucleate cells in the ascitic fluid.

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