Endothelial Cells Constituting Blood-nerve Barrier Have Highly Specialized Characteristics as Barrier-forming Cells
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- Sano Yasuteru
- Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
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- Shimizu Fumitaka
- Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
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- Nakayama Hiroto
- Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
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- Abe Masaaki
- Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
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- Maeda Toshihiko
- Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
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- Ohtsuki Sumio
- Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University
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- Terasaki Tetsuya
- Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University
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- Obinata Masuo
- Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University
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- Ueda Masatsugu
- The YS Institute, Inc.
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- Takahashi Ri-ichi
- The YS Institute, Inc.
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- Kanda Takashi
- Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine
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In autoimmune disorders of the peripheral nervous system (PNS) such as Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy, breakdown of the blood-nerve barrier (BNB) has been considered as a key step in the disease process. Hence, it is important to know the cellular property of peripheral nerve microvascular endothelial cells (PnMECs) constituting the bulk of BNB. Although many in vitro models of the blood-brain barrier (BBB) have been established, very few in vitro BNB models have been reported so far. We isolated PnMECs from transgenic rats harboring the temperature-sensitive SV40 large T-antigen gene (tsA58 rat) and investigated the properties of these “barrier-forming cells”. Isolated PnMECs (TR-BNBs) showed high transendothelial electrical resistance and expressed tight junction components and various types of influx as well as efflux transporters that have been reported to function at BBB. Furthermore, we confirmed the in vivo expression of various BBB-forming endothelial cell markers in the endoneurium of a rat sciatic nerve. These results suggest that PnMECs constituting the bulk of BNB have a highly specialized characteristic resembling the endothelial cells forming BBB.<br>
収録刊行物
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- Cell Structure and Function
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Cell Structure and Function 32 (2), 139-147, 2007
日本細胞生物学会
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詳細情報 詳細情報について
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- CRID
- 1390001204695265664
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- NII論文ID
- 40016192026
- 130004137525
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- NII書誌ID
- AA0060007X
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- COI
- 1:STN:280:DC%2BD1c%2FgslehsA%3D%3D
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- ISSN
- 13473700
- 03867196
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- NDL書誌ID
- 9603599
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- PubMed
- 18057801
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可
