Translocation of HSP27 and MKBP in Ischemic Heart.
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- Yoshida Ken-ichi
- Department of Legal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, Japan Department of Legal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan
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- Aki Toshihiko
- Department of Legal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, Japan
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- Harada Kazuki
- Department of Legal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, Japan
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- M.A. Shama Kazi
- Department of Legal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, Japan
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- Kamoda Yasuhisa
- Department of Legal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, Japan
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- Suzuki Atsushi
- Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama, Kanagawa 236-0004, Japan
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- Ohno Shigeo
- Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama, Kanagawa 236-0004, Japan
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Abstract
HSP27 and MKBP translocate from the cytosolic to myofibril fraction in ischemic rat heart as demonstrated by immunoblotting. Immunohistochemistry analysis showed that ischemia enhances the Z line labeling of HSP27 and MKBP. Two dimensional gel electrophoresis showed that ischemia increases the hyperphosphorylated form of HSP27. These data suggest that HSP27 and MKBP may be involved in the Z line protection against postischemic reperfusion injury.
Journal
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- Cell Structure and Function
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Cell Structure and Function 24 (4), 181-185, 1999
Japan Society for Cell Biology
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Keywords
Details 詳細情報について
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- CRID
- 1390001204696012672
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- NII Article ID
- 130004137301
- 10006225442
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- NII Book ID
- AA0060007X
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- COI
- 1:CAS:528:DyaK1MXmvVymtbs%3D
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- ISSN
- 13473700
- 03867196
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- NDL BIB ID
- 4869993
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- PubMed
- 10532352
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed