The cytologic features of endometrial glandular and stromal breakdown due to anovulatory cycles

DOI 53 References
  • NORIMATSU Yoshiaki
    Department of Medical Technology, Ehime Prefectural University of Health Sciences

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  • 無排卵周期に伴う endometrial glandular and stromal breakdown の細胞像
  • —Comparison of the conventional preparation method and LBC method—
  • —従来法と LBC 法の比較—

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For liquid-based cytology (LBC) in cases of endometrial glandular and stromal breakdown (EGBD), it has been thought that examination of the cellular features and comparison with the conventional preparation (CP) method are essential. In this study, the BD SurePathTM (SP) method was employed as the method for the LBC.<br>The results were as follows : Although the area of the smear prepared by the SP method was smaller than that in the LBC sample prepared using the CP method, the LBC preparation was adequate for examination of the relevant cells, and preparation of the smear with a clean background was possible ; The nuclei of the condensed clusters of stromal cells were reniform in shape and small in size, and the nuclear chromatin tended to show a darker tone. The nuclei of the metaplastic clumps with irregular protrusions were spindle-shaped and larger in size ; The SP method was remarkably advantageous in that the morphological characteristics of the nuclei were better preserved in the preparation obtained using the SP method than in that obtained using the CP method ; A more accurate diagnosis is possible by immunocytochemical examination for a combination of the following markers : CD10, CAM5.2, p53, cyclinA. Recognition of the light green body may be useful for accurate diagnosis of EGBD.<br>In conclusion, as for the results of the current study, it was expected that the SP method improve the diagnostic precision of endometrial cytology.

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