The relationship between HPV test and coloposcopy and follow up in patients with LSIL and HSIL in uterine cancer mass screening

DOI 1 Citations 40 References
  • MORIMURA Yutaka
    Fukushima Preservation Service Association of Health Department of Gynecology, Northern Fukushima Medical Center
  • TORAIWA Ryoko
    Fukushima Preservation Service Association of Health
  • SATO Nami
    Fukushima Preservation Service Association of Health
  • TSUKAHARA Takashi
    Fukushima Preservation Service Association of Health
  • SATO Mikako
    Fukushima Preservation Service Association of Health
  • SHIBATA Shinichi
    Fukushima Preservation Service Association of Health
  • WAKAKI Yu
    Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine
  • WATANABE Takahumi
    Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine
  • NISHIYAMA Hiroshi
    Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine
  • FUJIMORI Keiya
    Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine

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Other Title
  • 子宮がん集団検診で LSIL, HSIL 例への HPV 検査を併用した精密検査と経過追跡について

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Objective : To clarify the significance of human papillomavirus (HPV) test in squamous intraepithelial lesion (SIL), we carried out HPV test to women with SIL in uterine cervical cancer screening.<br>Study Design : We compared HPV test, coloposcopic biopsy and follow-up results in 190 women with LSIL, 76 women with HSIL suggested CIN2 and 69 women with HSIL suggested CIN3 diagnosed in uterine cervical cancer screening from April 2008 to March 2009.<br>Results : HPV test positivity was about 80% and showed no significant difference between LSIL, HSIL suggested CIN2 and HSIL suggested CIN3. Over CIN3 lesions were found 4.7% of LSIL, 32.9% of HSIL suggested CIN2 and 59.4% of HSIL suggested CIN3. HPV test showed no significant difference of detection rate over CIN3 lesion. HSIL suggested CIN2 with HPV negative showed significantly higher regression rate than those with HPV positive.<br>Conclusion : Among SIL, HPV test may be inadequate triage of coloposcopic biopsy for its high positivity. Colposcopic biopsy should be recommended in SIL. For high frequency of disappearance of atypical cells, long-range follow up may be interrupt in HSIL with both negative for HPV test or coloposcopic biopsy.

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