The Regulatory Mechanism of Serotonin Level in Rat Brain and Intestine
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- MINATOGAWA Yohsuke
- Department of Biochemistry, Wakayama Medical College
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- NOGUCHI Tomoo
- Department of Biochemistry, Wakayama Medical College
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- KIDO Ryo
- Department of Biochemistry, Wakayama Medical College
Bibliographic Information
- Other Title
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- A-1.セロトニンの脳及び腸内レベル調節機構に関する研究
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Description
Rat brain extract was found to catalyse the formation of 5-hydroxyindoleacetic acid from L-5-hydroxytryptophan in the presence of α-ketoglutarate, pyridoxal phosphate, NAD+ and iproniazide as a monoamine oxidase inhibitor. 5-Hydroxyindoleacetic acid was not formed in the absence of α-ketoglutarate. The omission of NAD+ from the incubation mixture decreased 5-hydroxyindole- acetic acid formation. These findings show that 5-hydroxyindoleacetic acid was produced from L-5-hydroxytryptophan via a transamination pathway which does not contain 5-hydroxytryptamine but 5-hydroxyindolepyruvic acid as an intermediate. The physiological significance of this pathway is discussed.
Journal
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- Proceedings of the Symposium on Chemical Physiology and Pathology
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Proceedings of the Symposium on Chemical Physiology and Pathology 13 (0), 2-4, 1974
Japan Society of Clinical Chemistry
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Details 詳細情報について
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- CRID
- 1390001204697025536
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- NII Article ID
- 130003355233
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- ISSN
- 21874085
- 03863417
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed