Studies on Hereditary Spherocytosis

DOI
  • TAKESHITA Masazumi
    Department of Biochemistry, School of Medicine and Department of Medical Technology, School of Paramedicine, Kanazawa University, Kanazawa
  • KITAO Takeshi
    Third Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa

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Other Title
  • A-2. 遺伝性球状赤血球症に関する研究
  • Effect of Chemical and Enzymic Modifiers on Passive Ion Permeability of Erythrocyte
  • Chemical及びEnzymic Modifierに対する赤血球のイオン受動透過性

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Description

Parachloromercuribenzenesulphonic acid (PCMBS), an agent which increases passive permeability of cations by reacting with sulfhydryl groups of the membrane, much less increases cation permeability in hereditary spherocytic (HS) red cells than normal red cells. Pronase which is thought to alterate the charged amino groups of the membrane, changes permeability of cations in the same degree with normal and HS red cells. Alteration of sulfhydryl groups of the membrane may be primarily involved in the changes of cation permeability in HS red cells.

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