Immunoglobulin G4-associated autoimmune pancreatitis—A case report—

  • KINOSHITA Yuichi
    Department of Cytopathology, Kansai Medical University Takii Hospital Department of Clinical Laboratory and Science, Kansai Medical University Takii Hospital
  • TAKASU Kosho
    Department of Cytopathology, Kansai Medical University Takii Hospital
  • YURI Takashi
    Department of Cytopathology, Kansai Medical University Takii Hospital Second Department of Pathology, Kansai Medical University
  • ICHIBE Kazuo
    Department of Cytopathology, Kansai Medical University Takii Hospital Department of Clinical Laboratory and Science, Kansai Medical University Takii Hospital
  • MATSUNAGA Shiho
    Department of Cytopathology, Kansai Medical University Takii Hospital Department of Clinical Laboratory and Science, Kansai Medical University Takii Hospital
  • TAKABATAKE Nozomi
    Department of Cytopathology, Kansai Medical University Takii Hospital Department of Clinical Laboratory and Science, Kansai Medical University Takii Hospital
  • NAGUMO Sachiko
    Department of Cytopathology, Kansai Medical University Takii Hospital
  • SHIKATA Nobuaki
    Department of Cytopathology, Kansai Medical University Takii Hospital

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Other Title
  • IgG4 関連自己免疫性膵炎の 1 例
  • Immunoglobulin G4-associated autoimmune pancreatitis^|^mdash;A case report^|^mdash;

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Background : Autoimmune pancreatitis (AIP) is an inflammatory disorder causing a mass that is often operated on as pancreatic cancer. We report such a case.<br>Case : A 67-year-old man reporting had dysgeusia and brown urine had intrahepatic bile duct dilation pointed out on computed tomography and obstructive jaundice diagnose due to a tumor. Cytology of the bile showed small, irregularly arranged clusters against the bile pigment background. Cells forming clusters showed irregular nuclei and mildly increased of fine granule-shaped chromatin. Histologically, the lesion showed fibrosis between the pancreatic duct and pancreatic lobule, with distinct lymphatic infiltration and IgG4-positive plasma cells.<br>Conclusion : AIP which is an inflammatory disorder. Steroid therapy is very effective in treating. An accurate diagnosis is thus needed to avoid surgical excision. Confirmation by EUS-FNA cytology may be necessary when we must refer the clinical background and conduct a serological investigation.

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