A trial of evaluating urine cytology based on the 2004 WHO classification, and comparative study of liquid-based cytology preparation and conventional ones

DOI 1 Citations 35 References
  • TAIRA Kiyomi
    Department of Clinical Laboratory, National Hospital Organization Hokkaido Cancer Center
  • AZUMA Manabu
    Department of Clinical Laboratory, National Hospital Organization Hokkaido Cancer Center
  • OKUYAMA Dai
    Department of Clinical Laboratory, National Hospital Organization Hokkaido Cancer Center
  • NAKAJIMA Manami
    Department of Clinical Laboratory, National Hospital Organization Hokkaido Cancer Center
  • SUZUKI Hiroaki
    Division of Pathology, National Hospital Organization Hokkaido Cancer Center
  • YAMASHIRO Katsushige
    Division of Pathology, National Hospital Organization Hokkaido Cancer Center

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  • 2004 年 WHO 分類に基づく病理組織診断による尿細胞診評価の試みおよび Liquid-based cytology (LBC) 標本と従来法標本の比較研究

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Objective : To verify the value of liquid-based cytology (LBC) in urine cytology and to determine differences in cytological features between conventional and LBC preparations.<br>Study Design : Subjects numbered 114 with primary bladder cancer undergoing preoperative urine cytology. This was, first, to determine the relationship between the 2004 World Health Organization histological classification of urinary tract tumors and the results of urine cytology and, second, to compare the sensitivities of using (1) the conventional preparation alone and (2) both the conventional preparation and LBC with CytoRich Red. We also reexamined the cytological features of the two preparations.<br>Results : Sensitivity in urine cytology differed in histological surface growth patterns. Sensitivity using both types of preparation was 84.3% and that using conventional preparation alone was 61.1%. Adding the LBC preparation clearly improved that using the conventional preparation alone, especially for low-grade tumors. Tumor cells, including large clustered cells on a LBC preparation, were increased, resulting in more successful cytodiagnosis. False-positive cases did not increase in number. Although cells appeared similar to those of LBC applied to other specimens, the distinction from conventional preparations was minimal.<br>Conclusion : The concurrent use of LBC preparations raised urine cytology sensitivity.

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