Hemopexins Suppress Phorbol Ester-induced Necrosis of Polymorphonuclear Leucocytes.
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- Suzuki Kingo
- Department of Biology, School of Education, Waseda University
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- Kato Hidenobu
- Department of Biology, School of Education, Waseda University
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- Sakuma Yasuyuki
- Department of Biology, School of Education, Waseda University
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- Namiki Hideo
- Department of Biology, School of Education, Waseda University
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抄録
It was recently reported that intravenous administration of phorbol 12-myristate 13-acetate (PMA) showed a therapeutic effect in myelocytic leukemia patients. However, we previously observed that, in serum-free conditions, polymorphonuclear leucocytes (PMNs) were killed rapidly by exposure to PMA, suggesting the possibility of serious side effects. In this study, we found that PMA-induced necrosis of PMNs was prevented by serum, suggesting the existence of a "necrosis-suppressing factor". Next we tried to identify the serum factor. The hemopexins we purified were found to suppress necrosis of PMNs in a dose-dependent fashion. Hemopexins alone could not suppress necrosis, however, as it required the coexistence of another macromolecule such as albumin. Albumin promoted the suppressive activity of hemopexins in a dose-dependent fashion. These results strongly suggest that serum hemopexins may rescue mature PMNs from necrosis in the PMA-administered leukemia patient as previously reported, resulting in avoidance of serious side effects.
収録刊行物
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- Cell Structure and Function
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Cell Structure and Function 26 (4), 235-241, 2001
日本細胞生物学会
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詳細情報 詳細情報について
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- CRID
- 1390001204697360768
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- NII論文ID
- 130004137397
- 30023110161
- 50000990441
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- NII書誌ID
- AA0060007X
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- COI
- 1:CAS:528:DC%2BD3MXosVWqsL8%3D
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- ISSN
- 13473700
- 03867196
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- NDL書誌ID
- 5954609
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- PubMed
- 11699640
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可