Background data of spontaneous tumors in F344/DuCrlCrlj rats

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  • Takanobu Kenji
    Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445, Hirasawa, Hadano, Kanagawa 257-0015, Japan
  • Aiso Shigetoshi
    Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445, Hirasawa, Hadano, Kanagawa 257-0015, Japan
  • Umeda Yumi
    Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445, Hirasawa, Hadano, Kanagawa 257-0015, Japan
  • Senoh Hideki
    Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445, Hirasawa, Hadano, Kanagawa 257-0015, Japan
  • Saito Misae
    Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445, Hirasawa, Hadano, Kanagawa 257-0015, Japan
  • Katagiri Taku
    Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445, Hirasawa, Hadano, Kanagawa 257-0015, Japan
  • Ikawa Naoki
    Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445, Hirasawa, Hadano, Kanagawa 257-0015, Japan
  • Ishikawa Hiroaki
    Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445, Hirasawa, Hadano, Kanagawa 257-0015, Japan
  • Mine Takashi
    Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445, Hirasawa, Hadano, Kanagawa 257-0015, Japan
  • Take Makoto
    Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445, Hirasawa, Hadano, Kanagawa 257-0015, Japan
  • Haresaku Mitsuru
    Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445, Hirasawa, Hadano, Kanagawa 257-0015, Japan
  • Matsumoto Michiharu
    Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445, Hirasawa, Hadano, Kanagawa 257-0015, Japan
  • Fukushima Shoji
    Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445, Hirasawa, Hadano, Kanagawa 257-0015, Japan

Bibliographic Information

Other Title
  • F344/DuCrlCrljラットの自然発生腫瘍
  • F344/DuCrlCrlj ラット ノ シゼン ハッセイ シュヨウ

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Abstract

Introduction: We investigated the 2-year survival rate and incidence of spontaneous tumors in F344/DuCrlCrlj rats used in carcinogenicity studies of chemical substances. Records for animals used in the control groups of carcinogenicity studies which were conducted during the last 10 years were obtained from the database of the Japan Bioassay Research Center (JBRC). Six hundred ninety-nine males and 550 females were used in 14 and 11 inhalation studies, respectively, and 500 animals of each sex were used in 10 male and 10 female oral studies. Methods: In each study, SPF (specific pathogen free) animals were housed for 2 years (104 weeks) as control groups in the carcinogenicity studies. All animals underwent necropsy and histopathological examination. Each study was conducted in accordance with the Good Laboratory Practice. Results: The incidence of interstitial cell tumors was highest in both inhalation studies and oral studies (inhalation studies 86.1%, oral studies 68.6%). Tumors which had an incidence of 6% or higher were adenoma of the pituitary, C-cell adenoma of the thyroid, and mononuclear cell leukemia (LGL leukemia) of the spleen in male and female rats; fibroma of the subcutaneous tissue, adrenal pheochromocytoma, and islet cell adenoma of the pancreas in male rats; and endometrial stromal polyps and fibroadenoma of the mammary gland in female rats. Tumors other than the above had rare incidence rates. A clear difference in the incidence of spontaneous tumors was not observed between the inhalation and oral studies. The incidences of spontaneous tumors in control groups of previous oral studies are similar to our findings. There are no other reports of the spontaneous tumor incidence in the control groups of inhalation studies using F344/DuCrlCrlj rats. The 2-year survival rate was about 77% in both the inhalation and oral studies, and a gender difference was not observed. The F344/DuCrlCrlj rats used at JBRC had a higher 2-year survival rate than F344/N rats. This difference is possibly due to the low incidence of LGL leukemia in the F344/DuCrlCrlj rat. Conclusions: The incidences of spontaneous tumors in F344/DuCrlCrlj rats used in control groups of both inhalation and oral studies during the last 10 years at JBRC are similar to each other and similar to those reported in other studies. This is the first report on the incidence of spontaneous tumors in inhalation studies and contributes to the toxicological evaluation of studies using F344/DuCrlCrlj rats.

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