Effective Production of Potent Cell Cycle Inhibitor Dehydrophenylahistin by a Combination of Chemical Racemization and Streptomyces Enzyme-catalyzed Conversion.
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- Kanzaki Hiroshi
- Laboratory of Bioresources Chemistry, Faculty of Agriculture, Okayama University
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- Ikeda Banri
- Laboratory of Bioresources Chemistry, Faculty of Agriculture, Okayama University
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- Nitoda Teruhiko
- Laboratory of Bioresources Chemistry, Faculty of Agriculture, Okayama University
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説明
An effective method was established for preparing the potent cell cycle inhibitor dehydrophenylahistin by a combination of chemical racemization of partially purified (±)-phenylahistin and enzymatic conversion of (−)-phenylahistin by the cell-free extract of Streptomyces albulus KO-23, an albonoursin-producing actinomycete. This method enables conversion of (+)-phenylahistin, which is present in the culture of Aspergillus ustus NSC-F038 and is not transformed by the Streptomyces enzyme, to dehydrophenylahistin.
収録刊行物
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- 日本放線菌学会誌
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日本放線菌学会誌 17 (1), 1-5, 2003
日本放線菌学会
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詳細情報 詳細情報について
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- CRID
- 1390001204701797504
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- NII論文ID
- 130004487523
- 80016018699
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- NII書誌ID
- AN10080091
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- DOI
- 10.3209/saj.17_1
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- COI
- 1:CAS:528:DC%2BD3sXmvFymsrc%3D
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- ISSN
- 18816371
- 09145818
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- NDL書誌ID
- 6622268
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可