Hormonal Determinants of Sex Differences in Passive Avoidance Behavior in the Rat

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  • ラットの受動的回避行動における性差と性ホルモン
  • ラット ノ ジュドウテキ カイヒ コウドウ ニ オケル セイサ ト セイ ホル

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It has been reported that female rats retain passive avoidance behavior more poorly than males (3, 5). The purpose of this study was to investigate the hormonal determinants of sex differences in passive avoidance behavior.<BR>On the first two days, each rat was placed in the white compartment of a black/white chamber and allowed to enter the black compartment. On Day 3, the rat was shocked upon entering the black compartment. During the retention session (on Days 4-10), shocks were not given and the number of trials was counted on which the rat entered the black compartment within five minutes.<BR>Among control animals, females entered the black compartment within five minutes more frequently than did males in the retention session. Gonadectomy of both sexes in adulthood eliminated this sex difference (Exp. I). Neonatal castration produced males whose passive avoidance behavior was indistinguishable from that of females (Exp. II), while neonatal testosteron injections masculinized female behavioral patterns (Exp. III).

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