<i>TET2</i> mutation in diffuse large B-cell lymphoma
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- Kubuki Yoko
- Department of Transfusion and Cell Therapy, University of Miyazaki Hospital Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
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- Yamaji Takumi
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
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- Hidaka Tomonori
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki Oncology Unit, University of Miyazaki Hospital
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- Kameda Takuro
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
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- Shide Kotaro
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
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- Sekine Masaaki
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
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- Kamiunten Ayako
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
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- Akizuki Keiichi
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
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- Shimoda Haruko
- Department of Transfusion and Cell Therapy, University of Miyazaki Hospital Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
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- Tahira Yuuki
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
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- Nakamura Kenichi
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
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- Abe Hiroo
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
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- Miike Tadashi
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
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- Iwakiri Hisayoshi
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
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- Tahara Yoshihiro
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki Oncology Unit, University of Miyazaki Hospital
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- Sueta Mitsue
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
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- Yamamoto Shojiro
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
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- Hasuike Satoru
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
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- Nagata Kenji
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki Liver Disease Center, University of Miyazaki Hospital
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- Kitanaka Akira
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
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- Shimoda Kazuya
- Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
Bibliographic Information
- Other Title
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- TET2 mutation in diffuse large B-cell lymphoma
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Abstract
<p>Ten-eleven translocation-2 (TET2) mutation is frequently observed in myeloid malignancies, and loss-of-function of TET2 is essential for the initiation of malignant hematopoiesis. TET2 mutation presents across disease entities and was reported in lymphoid malignancies. We investigated TET2 mutations in 27 diffuse large B-cell lymphoma (DLBCL) patients and found a frameshift mutation in 1 case (3.7%). TET2 mutation occurred in some populations of DLBCL patients and was likely involved in the pathogenesis of their malignancies.</p>
Journal
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- Journal of Clinical and Experimental Hematopathology
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Journal of Clinical and Experimental Hematopathology 56 (3), 145-149, 2017
The Japanese Society for Lymphoreticular Tissue Research