An Outbreak of Rabbit Hemorrhagic Disease in Shizuoka Prefecture

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  • 静岡県における兎出血病の発生
  • シズオカケン ニ オケル ウサギシュッケツビョウ ノ ハッセイ

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Abstract

Fifty three of 60 (88.3%) adult rabbits suddenly died within a period of 9 days at a tourist farm in Shizuoka Prefecture in March 1995. Three dead cases were histopathologically examined, revealing lesions characteristic of rabbit hemorrhagic disease (RHD) comprising necrotic hepatitis and disseminated intravascular coagulations in the lungs and kidneys. By immunostaining with antibody against RHD virus viral antigen was demonstrated within hepatocytes. Electron microscopy showed the presence of calicivirus-like particles in the cytoplasm of necrotic hepatocytes. The disease was experimentally reproduced in rabbits inoculated with liver homogenate from the affected cases, and calicivirus particles were purified from the infected liver homogenate. The present cases were the second outbreak of RHD in Japan following the cases in Hokkaido in 1994.

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