Gastric Carcinoid in Three Bearded Dragons

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  • KADEKARU Sho
    Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University,
  • SUZUKI Tetsuya
    横浜市開業
  • UNE Yumi
    Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University,

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  • フトアゴヒゲトカゲの胃原発カルチノイドの3例
  • フトアゴヒゲトカゲ ノ イ ゲンパツ カルチノイド ノ 3レイ

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Abstract

Gastric carcinoids were observed in three adult female bearded dragons (Pogona vitticeps). Macroscopically, large and transmural tumors were seen in the stomach of all cases, and Case 3 had hepatic metastasis. Microscopically, in all cases, infiltrative tumor cells proliferated without capsulation and formed nests and ribbon-like rows of cells. Pseudorosette formation was observed in Case 2. Some tumor cells were poorly adhesive, having scant cytoplasm and small round pyknotic nuclei. The other tumor cells had large, spindle shaped and bright nuclei. Immunohistochemically, the tumor cells were positive for chromogranin A and synaptophysin in all cases. Only Case 1 expressed cytokeratin. In electron microscopy, neuroendocrine granules averaging 220 nm in diameter were seen in the cytoplasm of the tumor cells in Case 3.

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