Effect of Ferrous Compounds to Reduce the Toxicity of Hexavalent Chromium on Mice

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  • SUSA NOBUYUKI
    School of Veterinary Medicine and Animal Sciences, Kitasato University
  • UENO SHUNJI
    School of Veterinary Medicine and Animal Sciences, Kitasato University
  • FURUKAWA YOSHINORI
    School of Veterinary Medicine and Animal Sciences, Kitasato University
  • UEYAMA SHIGENARU
    School of Veterinary Medicine and Animal Sciences, Kitasato University
  • OKA MASAHIDE
    School of Veterinary Medicine and Animal Sciences, Kitasato University

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Other Title
  • 6価クロムの生体毒性に対する2価鉄化合物の軽減効果
  • 6カ クロム ノ セイタイ ドクセイ ニ タイスル 2カ テツ カゴウブツ ノ

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Abstract

Ferrous compounds were examined for effects on mice to reduce the toxicity of hexavalent chromium. When a chromate (as K2Cr2O7) and FeCl2 simultaneusly injected intraperitoneally (i.p.) to mice, there was a remarkable decrease in chromate-induced lethality. In mice administered orally or i.p. with both chromate and FeCl2, the chromium content decreased in liver and kidneys, but increased in spleen and testis as compared with that in mice administered with the chromate alone. When injected i.p. with chromate and administered orally with FeCl2, or pre-injected i.p. with FeCl2 befor chromate injection, mice showed no remarkable alteration in the chromium content. FeSO4 and chromate injected i.p. also exerted the same influence as FeCl2. FeCl3 and Fe (SO4) 3, had little influence on the chromium content. In mice simultaneously injected i.p. with chromate and FeCl2, chromium excreted in urine was less than in mice administered with chromate alone.

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