Streptozotocin Therapy for Medical Management of Insulinoma in a Dog
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- SEKI Mamiko
- Animal Medical Center, Nihon University
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- ASANO Kazushi
- Animal Medical Center, Nihon University
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- OGIWARA Naoki
- Animal Medical Center, Nihon University
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- EDAMURA Kazuya
- Animal Medical Center, Nihon University
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- SHIBUYA Hisashi
- Animal Medical Center, Nihon University
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- WATARI Toshihiro
- Animal Medical Center, Nihon University
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- UCHIDA Kazuyuki
- 宮崎大学農学部
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- TANAKA Shigeo
- Animal Medical Center, Nihon University
Bibliographic Information
- Other Title
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- ストレプトゾトシンにより治療したインスリノーマの犬の1例
- ストレプトゾトシン ニ ヨリ チリョウ シタ インスリノーマ ノ イヌ ノ 1レイ
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Abstract
dog diagnosed as insulinoma with concurrent peripheral polyneuropathy was treated with surgical resection and postoperative streptozotocin (STZ) therapy. Beginning on the 62nd postoperative day, intravenous administration of STZ (500mg/m2) was performed every three weeks. The dog's blood glucose level returned to the normal range and neurological signs improved after the administration of two doses of STZ. At the third administration of STZ, recurrent hypoglycemia was identified. The dog's condition did not improve and a seizure followed. The dog was euthanatized due to the development of the hypoglycemic seizure on the 127th postoperative day. Normoglycemia had been maintained without severe side effects, such as renal dysfunction, f or two months after the operation. We therefore suggest that STZ therapy is useful in the medical management of canine insulinoma.
Journal
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- Journal of the Japan Veterinary Medical Association
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Journal of the Japan Veterinary Medical Association 58 (10), 692-696, 2005
Japan Veterinary Medical Association
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Details 詳細情報について
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- CRID
- 1390001204711320960
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- NII Article ID
- 130004052409
- 20000659478
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- NII Book ID
- AN00191857
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- COI
- 1:CAS:528:DC%2BD2MXhtFygsrjP
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- ISSN
- 21860211
- 04466454
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- NDL BIB ID
- 7689403
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed