Uveodermatologic Syndrome in a Japanese Akita Dog－Immunohistochemical Finding of Ocular Lesions

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  • 眼球病変の免疫組織化学的検索を実施したぶどう膜皮膚症候群の秋田犬の1例
  • ガンキュウ ビョウヘン ノ メンエキ ソシキ カガクテキ ケンサク オ ジッシ シタ ブドウマク ヒフ ショウコウグン ノ アキタイヌ ノ 1レイ

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Abstract

A Japanese Akita dog presented with blepharospasm and was diagnosed as having chronic pan-uveitis with of unknown cause. Steroid treatment improved the clinical signs and the treatment was discontinued. Subsequently, the dog presented with vision loss and bullous retinal detachment was observed. The clinical signs again improved with steroid treatment and once again treatment was discontinued. The third time, the dog presented with vision loss and secondary glaucoma had developed. The owner ordered euthanasia. After euthanasia, uveodermatologic syndrome was diagnosed via autopsy by characteristic pathological findings. Immunohistochemical analysis of the globes revealed CD3-positive T lymphocytes as the predominant infiltrating lymphocyte type, which was in contrast to a previous report detailing mainly B lymphocytes.

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