Intraperitoneal cisplatin chemotherapy for three dogs with reproductive tumors

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  • シスプラチンの腹腔内投与を行った犬の生殖器系腫瘍3例
  • シスプラチン ノ フククウ ナイ トウヨ オ オコナッタ イヌ ノ セイショクキケイ シュヨウ 3レイ

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Abstract

Three dogs were diagnosed with reproductive tumors after castration or ovariohysterectomy. Since the lesions metastasized or were at risk for metastasis, the dogs were referred for postoperative chemotherapy. Their histopathological diagnoses were ovarian adenocarcinoma disseminating to the peritoneum, ovarian granulosa cell tumor with vascular invasion, and seminoma metastasizing to the celiac lymph nodes. The dogs were treated four or five times with a dose of cisplatin 40-50 mg/m2 intraperitoneally-injected every three weeks. Two dogs showed no signs of metastases for 31 and 7 months, respectively. In the dog with nodal metastasis, administration of intraperitoneal cisplatin five times reduced the hypogastric lymph nodes from 56.4 mm ×26.5 mm to 45.7 mm ×17.9 mm.

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