カルシウムイオンおよびプロテインキナーゼＣのブリのリンパ球の増殖への関与

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タイトル別名
  • Role of Ca2+ and Protein Kinase C in the Proliferation of Yellowtail, Seriola quinqueradiata Lymphocytes.
  • カルシウム イオン オヨビ プロテイン キナーゼ C ノ ブリ ノ リンパキュ

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説明

A major route of signal transduction in the proliferation of mammalian lymphocytes is the phosphatidyl inositol (PI) pathway. This signaling pathway induces increase of intracellular Ca2+concentration and activation of protein kinase C (PKC) . This study investigated whether intracellular Ca2+and PKC are involved in the proliferation of yellowtail, Seriola quinqueradiatalymphocytes. Proliferative responses were assayed using the mitogen, concanavalin A (Con A) . Con A induced an increase of intracellular Ca2+concentration of yellowtail lymphocytes inducedby Con A. Proliferation of Con A-stimulated yellowtail lymphocytes was inhibited by the Ca2+channel blocker, Verapamil and PKC inhibitor, H-7. Furthermore, the calcium ionophore, A23187 and the PKC activator, TPA also stimulated yellowtail lymphocytes. From these results, it is apparent that the increase of intracellular Ca2+concentration and the activation of PKC are related with the proliferation of yellowtail lymphocytes as seen in mammals.

収録刊行物

  • 水産増殖

    水産増殖 44 (4), 439-443, 1996

    日本水産増殖学会

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