Radical Scavenging Properties of Indapamide and Renal Protection in Dahl Salt-Sensitive Rats.
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- Uehara Yoshio
- 2nd Department of Medicine, University of Tokyo
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- Kawabata Yukari
- 2nd Department of Medicine, University of Tokyo
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- Shirahase Hiroaki
- Kyoto Pharmaceutical Industries, Ltd.
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- Wada Katsuo
- Kyoto Pharmaceutical Industries, Ltd.
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- Hashizume Yukiko
- Kyoto Pharmaceutical Industries, Ltd.
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- Morishita Shigeyoshi
- Kyoto Pharmaceutical Industries, Ltd.
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- Numabe Atsushi
- Department of Medicine, Dokkyo University School of Medicine
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- Iwai Junichi
- Brookhaven National Laboratory
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- Matsuoka Hiroaki
- 2nd Department of Medicine, University of Tokyo
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- Sugimoto Tsuneaki
- 2nd Department of Medicine, University of Tokyo
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説明
We have found that indapamide has free radical scavenging properties and stimulates prostacyclin generation in vascular smooth muscle cells. In this study, we investigated whether indapamide exhibits radical scavenging effects in vivo and whether these properties are related to renal protection in Dahl salt-sensitive (Dahl S) rats. Indapamide (4mg/kg body weight per day for 5 weeks) ameliorated the development of hypertension in Dahl S rats fed a high salt (6% NaCl) diet. The blood pressure reduction was associated with a decrease in proteinuria, a decrease in urinary n-acetyl-β-D-glucosaminidase excretion, and an increase in glomerular filtration rate. Moreover, morphological investigation revealed improvement in glomerulosclerosis, renal tubular damage and intrarenal arterial injuries, seen in the salt-induced hypertension. These beneficial properties were accompanied by a significant decrease in the capacity for lipid peroxide formation in the renal homogenates. In contrast, trichloromethiazide, which reduced the blood pressure to the same extent as indapamide, did not lower lipid peroxide formation in the kidney or exert protective effects on the renal glomeruli or arteries. Thus, the evidence suggests that the diuretic indapamide exhibits radical scavenging effects on the kidney which may contribute to attenuating the renal injuries seen in salt-induced hypertension in Dahl S rats. (Hypertens Res 1992; 15: 17-26)
収録刊行物
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- Hypertension Research
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Hypertension Research 15 (1), 17-26, 1992
日本高血圧学会
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詳細情報 詳細情報について
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- CRID
- 1390001204720298752
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- NII論文ID
- 130003456116
- 30034931559
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- NII書誌ID
- AA10847079
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- COI
- 1:CAS:528:DyaK38XmsVGhsLw%3D
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- ISSN
- 13484214
- 09169636
- http://id.crossref.org/issn/09169636
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
