Practical application of HPC Film as an intraoral covering material.

DOI 1 Citations 3 References
  • KASASHI KUMIKO
    Department of Pharmacy, Hokkaido University Dental Hospital
  • HARADA SACHIKO
    Department of Pharmacy, Hokkaido University Dental Hospital
  • WADA IKUO
    Department of Pharmacy, Hokkaido University Dental Hospital
  • KOBAYASHI ICHIZOH
    Second Department of Oral Surgery, School of Dentistry, Hokkaido University
  • FUNAOKA KOUSEI
    Second Department of Oral Surgery, School of Dentistry, Hokkaido University
  • HIDA KYOUKO
    Second Department of Oral Surgery, School of Dentistry, Hokkaido University
  • TOTSUKA YASUNORI
    Second Department of Oral Surgery, School of Dentistry, Hokkaido University

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Other Title
  • ＨＰＣフィルムの口腔内被覆剤としての応用

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Abstract

When administering medication, the oral cavity presents specific problems in comparison with other organs. In other words, there are diverse factors such as the palate, the proximity to olfaction, the existence of sensitive tactus and the tongue, sputum and teeth.<BR>Carboxymethyl Cellulose Sodium (CMC) and Sodium Polyacrylate have been used as adhesive agents for the mucous membrane of the oral cavity in manufactured oral ointments and hospital preparations. However, even with the use of these agents, the adhesion time of oral ointments has not increased satisfactorily and the problem of the taste of the ingredients remains. This situation requires improvements for comfortable use of such ointments for all occasions.<BR>HPC Film consisting of Hydroxypropyl Cellulose (HPC), a water-soluble high-polymer was used as a covering material without active ingredients. After applying 10% Tetracycline CMC ointment to the buccal mucosa, lower buccal gingiva, soft palate and margin of tongue, they were covered by HPC Film. Changes over time in the presence of the ointment were compared between cases with and without HPC Film. It was found that by using a covering of HPC Film, adhesion time was markedly increased. Even in the tongue which was difficult to attach, the adhesionmaintenace time of oral ointment with HPC film indicated six-fold that without the film.

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