A Case of Ulcerative Colitis Complicated by the Perforation of a Toxic Megacolon

DOI
  • Sato Koichi
    Department of Surgery, Juntendo Izunagaoka Hospital, Juntendo University School of Medicine
  • Maekawa Takeo
    Department of Surgery, Juntendo Izunagaoka Hospital, Juntendo University School of Medicine
  • Yabuki Kiyotaka
    Department of Surgery, Juntendo Izunagaoka Hospital, Juntendo University School of Medicine
  • Maekawa Hiroshi
    Department of Surgery, Juntendo Izunagaoka Hospital, Juntendo University School of Medicine
  • Kudo Keizo
    Department of Surgery, Juntendo Izunagaoka Hospital, Juntendo University School of Medicine
  • Machida Michio
    Department of Surgery, Juntendo Izunagaoka Hospital, Juntendo University School of Medicine
  • Kushida Tomoaki
    Department of Surgery, Juntendo Izunagaoka Hospital, Juntendo University School of Medicine
  • Wada Ryo
    Department of Pathology, Juntendo Izunagaoka Hospital, Juntendo University School of Medicine
  • Matsumoto Michio
    Department of Pathology, Juntendo Izunagaoka Hospital, Juntendo University School of Medicine

Bibliographic Information

Other Title
  • Ｔｏｘｉｃ　ｍｅｇａｃｏｌｏｎを呈した潰よう性大腸炎穿孔の１例

Description

A 53-year-old woman was admitted to our hospital because of bloody stools on June, 2001. Colonoscopicfindings led to a diagnosis of ulcerative colitis, and the patient was treated with mesalazine andpredonine. Her condition worsened, and leukocytopheresis therapy was started. In addition, predonine andulinastatin were injected via the superior and inferior mesenteric arteries. Despite these treatments, theclinical symptoms became aggravated, and colonoscopic findings indicated a worsening of the ulcerativecolitis. On August, 2001, the patient underwent an emergency operation because a toxic megacolon wasdetected by plain abdominal X-ray and severe peritoneal signs were recognized. Intraoperatively, the wallof the entire large intestine was found to be very thin, and the cecum was perforated. The large intestinewas resected, and an ileostomy was performed. Endotoxin adsorption therapy was performed twice becausethe patient showed signs of systemic inflammatory response syndrome (SIRS). The general condition of thepatient gradually improved, and the patient was discharged from hospital on November, 2001.

Journal

Keywords

Details 詳細情報について

  • CRID
    1390001204734263680
  • NII Article ID
    130004243227
  • DOI
    10.11231/jaem1993.23.659
  • ISSN
    18824781
    13402242
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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