アラキドン酸代謝物の鼻粘膜血流に及ぼす影響

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  • EFFECTS OF ARACHIDONIC ACID METABOLITES ON NASAL MUCOSAL BLOOD FLOW

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Arachidonic acid cascade metabolites are known to exhibit numerous kinds of pathophysiological activities including manifestation and aggravation of allergy.<br>We studied changes in the nasal mucosal blood flow, total nasal volume and nasal airway resistance by topical application of arachidonic acid cascade metabolites in 10 adult volunteers (6 subjects allergic to house dust mites and 4 normal subjects).<br>The effect of test solutions (PGD2, TxA2 analogue U-46619) were studied by non-traumatic application of 100μl with a micropipette on the mucosal surface of the inferior turbinate. Blood flow in the nasal mucosa was measured by laser-doppler flowmeter (ALF21, Advance, Japan), nasal volume by acoustic rhinometer (RHIN2000, Rhinometrics, Denmark), and nasal airway resistance (NAR) by rhinomanometer (MPR2100, Nihon Kohden, Japan).<br>PGD2 induced a significant increase in nasal blood flow, nasal airway resistance and a decrease in total nasal volume.<br>TxA2 analog, U-46619, induced a dose dependent response increase in nasal blood flow and total nasal volume. In patients with allergic rhinitis, U-46619 was found to induce an increase in nasal airway resistance after 2 hours. PGD2 was demonstrated to cause vasodilatation in vivo in this study.<br>Findings indicate that ischemia reperfusion injury may be due to reduction of local blood flow, occur in the nasal mucosa during a TxA2 challenge, and result in edema and nasal blockage. The efficacy of TxA2 antagonist against nasal blockage in patients with allergic rhinitis may be its ability to protect the nasal mucosa from TP-mediated ischemia-reperfusion injury following repeated antigen exposure.

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