A Case of Pulmonary Pleomorphic Carcinoma That Could Hardly Be Distinguished from a Malignant Pleural Mesothelioma

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  • Kishimoto Kumiko
    Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center
  • Oshio Takeshi
    Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center
  • Nakano Chihiro
    Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center
  • Kurose Yoshiyuki
    Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center
  • Watanabe Kayo
    Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center
  • Kodaka Norio
    Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center
  • Yamagishi Tohru
    Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center
  • Yokouchi Yuki
    Department of Surgical Pathology, Toho University Ohashi Medical Center
  • Matsuse Hiroto
    Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center

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Other Title
  • 悪性胸膜中皮腫との鑑別を要した肺多形癌の1例

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Abstract

<p>Background. Pleomorphic carcinoma is defined as either a non-small cell lung carcinoma combined with neoplastic spindle and/or giant cells or a carcinoma that consists of only spindle and giant cells. At least 10% of the carcinoma should comprise spindle and/or giant cells for it to be classified as a pleomorphic carcinoma. Since it rarely occurs, few case reports have been reported. Case. A 72-year-old male visited our hospital due to exertional dyspnea. A chest X-ray and computed tomography revealed right pleural effusion and multiple pleural nodules. Based on thoracoscopic pleural biopsy, a history of asbestos exposure and his clinical course, we diagnosed malignant pleural mesothelioma. Thereafter the tumor increased expansively and he died. Autopsy confirmed a pleomorphic carcinoma of lung. Conclusions. Generally the diagnosis of pleomorphic carcinoma of lung is rarely established since it requires large tissue specimens by surgical resection and it is often diagnosed as other pulmonary tumors. The frequency of pleomorphic carcinoma of lung is rare and its clinical course is heterogeneous. Further accumulation of the number of cases is necessary.</p>

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