Effect of 6%HES70/0.5（Salinhes<sup>®</sup>）and Lactated Ringer（Solulact<sup>®</sup>）Infusion on Circulating Blood Volume, Oxygenation, Electrolyte and Acid-base Balance

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  • 6％HES70/0.5（サリンヘス<sup>Ⓡ</sup>）と乳酸リンゲル液（ソルラクト<sup>Ⓡ</sup>）の容量効果，酸素化，電解質・酸塩基平衡への影響の検討

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<p>We evaluated the effect of volume expansion and the fluctuation of oxygenation, electrolyte and acid-base balance after 30 min bolus intravenous infusion of 1 liter 6%HES70/0.5（Salinhes®）and lactated Ringer（Solulact®）. Seventy-two patients undergoing laparotomy with general anesthesia were randomly divided into a Salinhes® infusion group（n=36）and a Solulact® infusion group（n=36）. The volume expansion effects of Salinhes® and Solulact® were 78.4% and 36.8% of infused volume, respectively. Plasma potassium, chloride and bicarbonate ions and base excess fluctuated significantly after Salinhes® infusion. PaO2/FiO2 ratio deteriorated significantly after Solulact® infusion, though there was no significant difference between the groups in the relative variation of oxygenation. In rapid infusion, the volume expansion effects of both Salinhes® and Solulact® can be more than expected. However, attention should be paid to the electrolyte and acid-base balance disturbance after Salinhes® infusion and the deterioration of oxygenation after Solulact® infusion.</p>

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