Neuromuscular Disorders Affecting the Action of Rocuronium

DOI 1 Citations 58 References
  • NARIMATSU Eichi
    Department of Anesthesiology, Sapporo Medical University School of Medicine Department of Traumatology and Critical Care Medicine, Sapporo Medical University School of Medicine
  • NIIYA Tomohisa
    Department of Anesthesiology, Sapporo Medical University School of Medicine

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  • 特殊な状態・病態におけるロクロニウムの使い方と留意点―重症筋無力症・筋疾患などの神経筋疾患―

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 Changes in functions of neuromuscular junctions induced by neuromuscular or muscular disorder influence actions of rocuronium and other non-depolarizing neuromuscular blockers. In myasthenia gravis and Lambert-Eaton syndrome, the action of rocuronium is reinforced due to dysfunction of neuromuscular transmission. Action of rocuronium is often enhanced in Duchenne-type muscular dystrophy and myotonic dystrophy, myopathies that impair not only the function of muscle fibers but also the function of neuromuscular junctions. Sepsis often attenuates the action of rocuronium by modulating the function of neuromuscular junctions.

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