Anesthesia and Cardiovagal Baroreflex Responses

  • TANAKA Makoto
    Department of Anesthesiology/Critical Care Medicine, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba

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  • 麻酔と心臓迷走神経反射

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  Despite the 70-year-long research history of arterial baroreflex function, it has only been a decade since the clinical implications of this fundamental circulatory reflex have been clearly defined. In 1998, the ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) study published in the Lancet first demonstrated the prognostic value of cardiovagal baroreflex gain after myocardial infarction. Another important discovery in the last decade has been the gender difference in cardiovagal baroreflex function. In addition to these, methodologies of measuring baroreflex gains and effects of anesthetics and anesthesia-related medications on these reflex responses will be briefly discussed.


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