The Effects of Landiolol on Cardiac Index before and during Propofol Anesthesia

DOI 28 References
  • TANAKA Katsuya
    Department of Anesthesiology, Tokushima University School of Medicine
  • KAWANO Takashi
    Department of Anesthesiology, Tokushima University School of Medicine
  • OKADA Tsuyoshi
    Department of Anesthesiology, Tokushima University School of Medicine
  • EGUCHI Satoru
    Department of Dental Anesthesiology, Tokushima University School of Dentistry
  • OSHITA Shuzo
    Department of Anesthesiology, Tokushima University School of Medicine

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  • 意識下およびプロポフォール麻酔中の心係数に及ぼすランジオロール単回投与の影響

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 We investigated the effects of a novel, highly cardioselective short-acting β-blocker, landiolol on cardiac index with or without propofol anesthesia. Seven ASA class I - II patients received landiolol (0.1 mg/kg) before induction of anesthesia and during a target controlled infusion of propofol (effect-site concentration 2-4μg/ml) . We measured beat-to-beat heart rate (HR) , cardiac index (CI) , stroke volume index (SVI) , and end diastolic volume index (EDVI) by using the method of transthoracic bioimpedance measurement. HR and CI significantly decreased after landiolol injection in awake patients (86% and 89% of control value, respectively) , while SVI and EDVI did not change. This action was independent of propofol anesthesia. Our results suggest that 0.1 mg/kg bolus injection of landiolol induces a decrease in CI, which is associated with a decrease in HR.

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