A Case of Argatroban Use during On-pump Cardiac Surgery in a Patient with Heparin Resistance

DOI Web Site 4 References Open Access

Bibliographic Information

Other Title
  • ヘパリン抵抗性患者の開心術においてアルガトロバンを使用して人工心肺管理を行った1症例

Search this article

Description

Anticoagulation management during cardiac surgery is difficult in patients with heparin resistance. Here we report a patient with heparin resistance who underwent on-pump cardiac surgery with the use of argatroban during cardiopulmonary bypass (CPB). A 44-year-old man with a history of hypertension and hyperlipidemia was scheduled for aortic valve replacement. His platelet count was 108×104. The activated clotting time (ACT) remained below 400 seconds despite 500 IU/kg heparin and antithrombin supplementation. Argatroban was selected for anticoagulation during CPB. Argatroban was started with a bolus dose of 0.25 mg/kg, followed by an infusion of 5-8 μg/kg/min. ACT was maintained over 400 seconds during CPB. No complications such as thrombosis or excessive bleeding were observed either during CPB or the perioperative period.

Journal

References(4)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top